There is a launch of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors within the dorsal horn to decrease afferent pain transmission and create analgesia. Hence, drugs like clonidine that concentrate on alpha-2 receptors can influence the transmission of pain. You may be able to explain https://bookmark-share.com/story19816060/onolidine-an-overview