If you are not employing a Python distribution from Homebrew you might be able to immediate Cynthion to the right place by explicitly location DYLD_FALLBACK_LIBRARY_PATH to the location of the libusb native library. Apollo: the firmware that runs on Cynthion's debug controller and which is responsible for configuring its FPGA https://cynthion51739.tdlwiki.com/1253310/getting_my_cynthion_to_work