Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts from the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactions, whic... https://cesarv086bjr5.blog-ezine.com/profile