Chemotherapy was potentiated by E7449 and one agent had significant antitumor activity in BRCA-deficient xenografts. Moreover, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, probably by means of TNKS inhibition. In keeping with this probability, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and noticeably altered expression of https://carlosk666has7.wikiinside.com/user