At present, there are two kinds of experiments on itaconate: Irg1−/− macrophages plus the regulatory result of itaconate derivatives. Both of these final results were being complementary and unveiled which the regulatory mechanisms of itaconate involved alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription variable 3 (ATF3) https://7-methylxanthine36799.oblogation.com/29288492/the-smart-trick-of-ncoa4-9a-that-nobody-is-discussing