DNA ligases seal five′-PO4 and 3′-OH polynucleotide ends by using a few nucleotidyl transfer ways involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are crucial guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal constructions of DNA ligases certain to nucleotide and nucleic acid substrates have https://lechf678phb2.topbloghub.com/profile